Marine Cytotoxin Santacruzamate A Derivatives as Potent HDAC1-3 Inhibitors and Their Synergistic Anti-Leukemia Effects with Venetoclax.

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作者： Wanting,Hao ^[1] ; Leyan,Wang ^[1] ; Tongqiang,Xu ^[1] ; Geng,Jia ^[1] ; Yuqi,Jiang ^[1] ; Chong,Qin ^[1] ; Xiaoyang,Li ^[1]

作者单位： Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. ^[1]

关键词 AML cell apoptosis Santacruzamate A Venetoclax class I HDAC inhibitors combination therapy

主题词人类(Humans);磺胺类(Sulfonamides);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);药物协同作用(Drug Synergism);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);抗肿瘤药(Antineoplastic Agents);组蛋白脱乙酰基酶1(Histone Deacetylase 1);组蛋白脱乙酰基酶类(Histone Deacetylases);动物(Animals);半胱氨酸天冬氨酸蛋白酶3(Caspase 3)

DOI 10.3390/md22060250

PMID 38921561

发布时间 2024-06-28

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Marine drugs

2024年22卷6期

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Marine Cytotoxin Santacruzamate A Derivatives as Potent HDAC1-3 Inhibitors and Their Synergistic Anti-Leukemia Effects with Venetoclax.

Marine drugs

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Marine drugs

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Marine Cytotoxin Santacruzamate A Derivatives as Potent HDAC1-3 Inhibitors and Their Synergistic Anti-Leukemia Effects with Venetoclax.

Marine drugs

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Marine drugs

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