Chronic Mexiletine Administration Increases Sodium Current in Non-Diseased Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

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第一作者： Giovanna,Nasilli

第一单位： Department of Experimental Cardiology, Amsterdam University Medical Center, University of Amsterdam, Heart Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.;Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, 1105 AZ Amsterdam, The Netherlands.

作者： Giovanna,Nasilli ^[1] ; Arie O,Verkerk ^[2] ; Molly,O'Reilly ^[1] ; Loukia,Yiangou ^[3] ; Richard P,Davis ^[4] ; Simona,Casini ^[1] ; Carol Ann,Remme ^[1]

作者单位： Department of Experimental Cardiology, Amsterdam University Medical Center, University of Amsterdam, Heart Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.;Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, 1105 AZ Amsterdam, The Netherlands. ^[1] Department of Experimental Cardiology, Amsterdam University Medical Center, University of Amsterdam, Heart Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.;Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, 1105 AZ Amsterdam, The Netherlands.;Department of Medical Biology, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. ^[2] Department of Anatomy and Embryology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands. ^[3] Department of Anatomy and Embryology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands.;The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands. ^[4]

关键词 cardiac electrophysiology hiPSC-CMs ion channels sodium current therapy

DOI 10.3390/biomedicines12061212

PMID 38927420

发布时间 2024-06-29

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Biomedicines

2024年12卷6期

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Chronic Mexiletine Administration Increases Sodium Current in Non-Diseased Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

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Chronic Mexiletine Administration Increases Sodium Current in Non-Diseased Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Biomedicines

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