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5-HT<sub>6</sub> receptor neutral antagonists protect astrocytes: A lesson from 2-phenylpyrrole derivatives.

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第一作者： Marcin,Drop

第一单位： Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688, Kraków, Poland; IBMM, Université de Montpellier, CNRS, ENSCM, 34095, Montpellier, France.

作者： Marcin,Drop ^[1] ; Paulina,Koczurkiewicz-Adamczyk ^[2] ; Ophélie,Bento ^[3] ; Wojciech,Pietruś ^[4] ; Grzegorz,Satała ^[4] ; Klaudia,Blicharz-Futera ^[2] ; Vittorio,Canale ^[2] ; Katarzyna,Grychowska ^[2] ; Xavier,Bantreil ^[5] ; Elżbieta,Pękala ^[2] ; Rafał,Kurczab ^[4] ; Andrzej J,Bojarski ^[4] ; Severine,Chaumont-Dubel ^[6] ; Philippe,Marin ^[6] ; Frédéric,Lamaty ^[7] ; Paweł,Zajdel ^[8]

作者单位： Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688, Kraków, Poland; IBMM, Université de Montpellier, CNRS, ENSCM, 34095, Montpellier, France. ^[1] Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688, Kraków, Poland. ^[2] IBMM, Université de Montpellier, CNRS, ENSCM, 34095, Montpellier, France; Institut de Génomique Fonctionelle, Université de Montpellier, CNRS INSERM, 34094, Montpellier, France. ^[3] Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-343, Kraków, Poland. ^[4] IBMM, Université de Montpellier, CNRS, ENSCM, 34095, Montpellier, France; Institut Universitaire de France (IUF), France. ^[5] Institut de Génomique Fonctionelle, Université de Montpellier, CNRS INSERM, 34094, Montpellier, France. ^[6] IBMM, Université de Montpellier, CNRS, ENSCM, 34095, Montpellier, France. ^[7] Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688, Kraków, Poland. Electronic address: pawel.zajdel@uj.edu.pl. ^[8]

关键词 2-phenylpyrrole 5-HT(6) receptor Constitutive activity Cytoprotection Human astrocytes Inverse agonism Neutral antagonism