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An aptamer-mediated base editing platform for simultaneous knockin and multiple gene knockout for allogeneic CAR-T cells generation.

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第一作者： Immacolata,Porreca

第一单位： Revvity, 8100 Cambridge Research Park, Cambridge CB25 9TL, UK. Electronic address: immacolata.porreca@revvity.com.

作者： Immacolata,Porreca ^[1] ; Robert,Blassberg ^[2] ; Jennifer,Harbottle ^[2] ; Bronwyn,Joubert ^[2] ; Olga,Mielczarek ^[2] ; Jesse,Stombaugh ^[3] ; Kevin,Hemphill ^[3] ; Jonathan,Sumner ^[4] ; Deividas,Pazeraitis ^[4] ; Julia Liz,Touza ^[5] ; Margherita,Francescatto ^[5] ; Mike,Firth ^[4] ; Tommaso,Selmi ^[2] ; Juan Carlos,Collantes ^[6] ; Zaklina,Strezoska ^[3] ; Benjamin,Taylor ^[4] ; Shengkan,Jin ^[7] ; Ceri M,Wiggins ^[2] ; Anja,van Brabant Smith ^[3] ; John J,Lambourne ^[2]

作者单位： Revvity, 8100 Cambridge Research Park, Cambridge CB25 9TL, UK. Electronic address: immacolata.porreca@revvity.com. ^[1] Revvity, 8100 Cambridge Research Park, Cambridge CB25 9TL, UK. ^[2] Revvity, 2650 Crescent Drive, Lafayette, CO 80026, USA. ^[3] AstraZeneca, Discovery Sciences, R&D, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, UK. ^[4] AstraZeneca, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Pepparedsleden 1, 431 83 Mölndal, Sweden. ^[5] Departamento de Biotecnología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Campus Cumbayá, Casilla Postal 17-1200-841, Quito 170901, Ecuador. ^[6] Pharmacology Department, Rutgers, The State University of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854, USA. ^[7]

关键词 CRISPR advanced genome editing allogeneic cell therapy base editing gene editing knockin knockout multiple base editing multiple gene knockout transgene integration

医学主题词人类(Humans);基因敲除技术(Gene Knockout Techniques);适体, 核苷(Aptamers, Nucleotide);T淋巴细胞(T-Lymphocytes);免疫疗法, 过继(Immunotherapy, Adoptive);基因敲入技术(Gene Knock-In Techniques);转基因(Transgenes)

DOI 10.1016/j.ymthe.2024.06.033

PMID 38937969

发布时间 2024-09-19

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准确一般字义偏差语意偏离译文作用小提交