Epitope-specific antibody fragments block aggregation of AGelD187N, an aberrant peptide in gelsolin amyloidosis.

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第一作者： Laura,Leimu

第一单位： R&D, Orion Pharma, Orion Corporation, Turku, Finland; Faculty of Medicine, Institute of Biomedicine, University of Turku, Turku, Finland. Electronic address: laura.leimu@orionpharma.com.

作者： Laura,Leimu ^[1] ; Patrik,Holm ^[2] ; Anna,Gąciarz ^[3] ; Oskar,Haavisto ^[4] ; Stuart,Prince ^[5] ; Ullamari,Pesonen ^[6] ; Tuomas,Huovinen ^[4] ; Urpo,Lamminmäki ^[7]

作者单位： R&D, Orion Pharma, Orion Corporation, Turku, Finland; Faculty of Medicine, Institute of Biomedicine, University of Turku, Turku, Finland. Electronic address: laura.leimu@orionpharma.com. ^[1] R&D, Orion Pharma, Orion Corporation, Turku, Finland; Department of Life Technologies, University of Turku, Turku, Finland; Organon R&D Finland, Turku, Finland. ^[2] R&D, Orion Pharma, Orion Corporation, Turku, Finland; Mobidiag, A Hologic Company, Espoo, Finland. ^[3] Department of Life Technologies, University of Turku, Turku, Finland. ^[4] R&D, Orion Pharma, Orion Corporation, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland. ^[5] Faculty of Medicine, Institute of Biomedicine, University of Turku, Turku, Finland. ^[6] Department of Life Technologies, University of Turku, Turku, Finland. Electronic address: urplammi@utu.fi. ^[7]

关键词 aggregation inhibition amyloid antibody antibody engineering drug discovery gelsolin amyloidosis (AGel amyloidosis)phage display protein misfolding

主题词人类(Humans);钙结合微丝蛋白(Gelsolin);表位(Epitopes);淀粉样变性(Amyloidosis);淀粉样蛋白(Amyloid);免疫球蛋白Fab片段(Immunoglobulin Fab Fragments)

DOI 10.1016/j.jbc.2024.107507

PMID 38944121

发布时间 2024-10-09

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