In-depth mapping of DNA-PKcs signaling uncovers noncanonical features of its kinase specificity.

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作者： Shannon,Marshall ^[1] ; Marcos V A S,Navarro ^[2] ; Carolline F R,Ascenҫão ^[1] ; Diego,Dibitetto ^[3] ; Marcus B,Smolka ^[4]

作者单位： Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA. ^[1] Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA; IFSC Institute of Physics of São Carlos, University of São Paulo, São Carlos, São Paulo, Brazil. Electronic address: mvn23@cornell.edu. ^[2] Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA; Department of Experimental Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy. ^[3] Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA. Electronic address: mbs266@cornell.edu. ^[4]

关键词 DNA damage response DNA-dependent serine/threonine protein kinase (DNA-PK)cellular signaling ionizing radiation kinase interplay kinase specificity phosphoproteomics phosphorylation motif

主题词 DNA活化蛋白激酶(DNA-Activated Protein Kinase);人类(Humans);磷酰化(Phosphorylation);信号传导(Signal Transduction);底物特异性(Substrate Specificity);氨基酸特征结构(Amino Acid Motifs)

DOI 10.1016/j.jbc.2024.107513

PMID 38945450

发布时间 2024-10-23

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