Dual-Targeting of the HER2 Cancer Receptor with an Antibody-Directed Enzyme and a Nanobody-Guided MMAE Prodrug Scaffold.

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作者： Jakob Melgaard,Smidt ^[1] ; Anders,Märcher ^[1] ; Mads Koch,Skaanning ^[1] ; Kassem,El-Chami ^[1] ; Laura,Teodori ^[2] ; Marjan,Omer ^[2] ; Jørgen,Kjems ^[2] ; Kurt V,Gothelf ^[1]

作者单位： Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, 8000, Aarhus, Denmark. ^[1] Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 14, 8000, Aarhus, Denmark. ^[2]

关键词 ADEPT Bioconjugation Nanobody Prodrug aTNA

主题词药物前体(Prodrugs);人类(Humans);寡肽类(Oligopeptides);神经氨酸酶(Neuraminidase);细胞系, 肿瘤(Cell Line, Tumor);抗肿瘤药(Antineoplastic Agents);免疫轭合物(Immunoconjugates)

DOI 10.1002/cbic.202400437

PMID 38945824

发布时间 2024-11-08

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