Discovery of a first-in-class protein degrader for the c-ros oncogene 1 (ROS1).

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作者： Jiawen,Yang ^[1] ; Yifan,Wu ^[2] ; Qiaoliang,Zhu ^[3] ; Xiaojuan,Qu ^[2] ; Hongyue,Ou ^[2] ; Haixia,Liu ^[4] ; Yongqi,Wei ^[3] ; Di,Ge ^[3] ; Chunlai,Lu ^[5] ; Biao,Jiang ^[6] ; Xiaoling,Song ^[7]

作者单位： Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China; Shanghai Clinical Research and Trial Center, Shanghai 201210, China. ^[1] Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. ^[2] Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. ^[3] Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China; School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China. ^[4] Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: lu.chunlai@zs-hospital.sh.cn. ^[5] Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China; CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address: jiangbiao@shanghaitech.edu.cn. ^[6] Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China. Electronic address: songxl@shanghaitech.edu.cn. ^[7]

关键词 Lorlatinib Non-small cell lung cancer PROTAC ROS1 Target protein degradation