换一批Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response.
第一作者：
Brooke A,Pereira
第一单位：
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.
作者：
Brooke A,Pereira [1]
;
Shona,Ritchie [1]
;
Cecilia R,Chambers [1]
;
Katie A,Gordon [1]
;
Astrid,Magenau [1]
;
Kendelle J,Murphy [1]
;
Max,Nobis [2]
;
Victoria M,Tyma [3]
;
Ying Fei,Liew [3]
;
Morghan C,Lucas [4]
;
Marjan M,Naeini [5]
;
Deborah S,Barkauskas [6]
;
Diego,Chacon-Fajardo [7]
;
Anna E,Howell [3]
;
Amelia L,Parker [1]
;
Sean C,Warren [1]
;
Daniel A,Reed [1]
;
Victoria,Lee [3]
;
Xanthe L,Metcalf [3]
;
Young Kyung,Lee [3]
;
Luke P,O'Regan [3]
;
Jessie,Zhu [1]
;
Michael,Trpceski [1]
;
Angela R M,Fontaine [8]
;
Janett,Stoehr [3]
;
Romain,Rouet [9]
;
Xufeng,Lin [10]
;
Jessica L,Chitty [1]
;
Sean,Porazinski [7]
;
Sunny Z,Wu [11]
;
Elysse C,Filipe [1]
;
Antonia L,Cadell [7]
;
Holly,Holliday [12]
;
Jessica,Yang [1]
;
Michael,Papanicolaou [1]
;
Ruth J,Lyons [3]
;
Anaiis,Zaratzian [13]
;
Michael,Tayao [13]
;
Andrew,Da Silva [13]
;
Claire,Vennin [14]
;
Julia,Yin [7]
;
Alysha B,Dew [15]
;
Paul J,McMillan [16]
;
Leonard D,Goldstein [17]
;
Ira W,Deveson [5]
;
David R,Croucher [7]
;
Michael S,Samuel [18]
;
Hao-Wen,Sim [19]
;
Marcel,Batten [3]
;
Lorraine,Chantrill [20]
;
Sean M,Grimmond [21]
;
Anthony J,Gill [22]
;
Jaswinder,Samra [23]
;
Thomas R,Jeffry Evans [24]
;
Takako,Sasaki [25]
;
Tri G,Phan [26]
;
Alexander,Swarbrick [1]
;
Owen J,Sansom [24]
;
Jennifer P,Morton [24]
;
Australian Pancreatic Cancer Matrix Atlas (APMA) [7]
;
Australian Pancreatic Cancer Genome Initiative (APGI) [27]
;
Marina,Pajic [1]
;
Benjamin L,Parker [1]
;
David,Herrmann [1]
;
Thomas R,Cox ;
Paul,Timpson
作者单位：
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.
[1]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.;Intravital Imaging Expertise Center, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
[2]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
[3]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.;Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain.;Universitat Pompeu Fabra (UPF), Barcelona, Spain.
[4]
School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.;Genomics and Inherited Disease Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
[5]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.;ACRF INCITe Intravital Imaging Centre, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
[6]
School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.;Translational Oncology Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
[7]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.;ACRF INCITe Intravital Imaging Centre, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
[8]
School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.;Immune Biotherapies Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
[9]
Data Science Platform, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
[10]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.;Genentech Inc., South San Francisco, CA, USA.
[11]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.;Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Kensington, New South Wales, Australia.
[12]
Histopathology Platform, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
[13]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.;Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands.;Oncode Institute, Amsterdam, Netherlands.
[14]
Centre for Advanced Histology & Microscopy, Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.
[15]
Centre for Advanced Histology & Microscopy, Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.;Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.;Biological Optical Microscopy Platform, The University of Melbourne, Parkville, Victoria, Australia.
[16]
School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.;Data Science Platform, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
[17]
Centre for Cancer Biology, An Alliance of SA Pathology and University of South Australia, Adelaide, South Australia, Australia.;Basil Hetzel Institute for Translational Health Research, Queen Elizabeth Hospital, Woodville South, South Australia, Australia.
[18]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.;NHMRC Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia.;Department of Medical Oncology, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia.
[19]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.;Department of Medical Oncology, Illawarra Shoalhaven Local Health District, Wollongong, New South Wales, Australia.
[20]
Centre for Cancer Research and Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.
[21]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.;NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.;Sydney Medical School, University of Sydney, Camperdown, New South Wales, Australia.
[22]
Department of Surgery, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
[23]
Cancer Research UK Beatson Institute, Glasgow, UK.;School of Cancer Sciences, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
[24]
Department of Biochemistry, Faculty of Medicine, Oita University, Oita, Japan.
[25]
School of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.;Precision Immunology Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
[26]
Department of Anatomy and Physiology, University of Melbourne, Parkville, Victoria, Australia.
[27]
医学主题词
动物(Animals);人类(Humans);小鼠(Mice);钙结合蛋白质类(Calcium-Binding Proteins);癌, 胰腺管(Carcinoma, Pancreatic Ductal);细胞黏附分子(Cell Adhesion Molecules);细胞系, 肿瘤(Cell Line, Tumor);脱氧胞苷(Deoxycytidine);疾病模型, 动物(Disease Models, Animal);纤维化(Fibrosis);胰腺肿瘤(Pancreatic Neoplasms);蛋白质组学(Proteomics)
DOI
10.1126/sciadv.adl1197
PMID
38959305
发布时间
2025-06-27
基金项目
- 浏览3
Science advances
Science advances
2024年10卷27期
eadl1197页
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