首页> Cell reports. Medicine> Pan-cancer mapping of single CD8<sup>+</sup> T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity.

Pan-cancer mapping of single CD8<sup>+</sup> T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity.

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第一作者： Katherine,Tooley

第一单位： The Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA; Division of Medical Sciences, Harvard Medical School, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

作者： Katherine,Tooley ^[1] ; Livnat,Jerby ^[2] ; Giulia,Escobar ^[3] ; S Harsha,Krovi ^[3] ; Davide,Mangani ^[3] ; Gitanjali,Dandekar ^[3] ; Hanning,Cheng ^[3] ; Asaf,Madi ^[4] ; Ella,Goldschmidt ^[4] ; Conner,Lambden ^[3] ; Rajesh K,Krishnan ^[3] ; Orit,Rozenblatt-Rosen ^[5] ; Aviv,Regev ^[6] ; Ana C,Anderson ^[7]

作者单位： The Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA; Division of Medical Sciences, Harvard Medical School, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ^[1] Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: ljerby@stanford.edu. ^[2] The Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ^[3] Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. ^[4] Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[5] Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute and Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: regev.aviv@gene.com. ^[6] The Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: acanderson@bwh.harvard.edu. ^[7]

关键词 CD28 CXCR6 T cell dysfunction T cell exhaustion TCF1 human meta-analysis pan-cancer single cell