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An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases.

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第一作者: Akiko,Oguchi
第一单位: RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan.;Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
作者单位: RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan.;Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. [1] Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. [2] RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;IFOM ETS - the AIRC Institute of Molecular Oncology, Milan, Italy. [3] Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan.;Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. [4] Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan. [5] IFOM ETS - the AIRC Institute of Molecular Oncology, Milan, Italy. [6] Genome Immunobiology RIKEN Hakubi Research Team, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. [7] Division of Molecular Pathology, Department of Cancer Biology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.;Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.;Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. [8] RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan.;Department of Medical Systems Genomics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. [9] RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama City University, Yokohama, Japan. [10] RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. [11] K.K. DNAFORM, Yokohama, Japan. [12] Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. [13] RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.;Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. [14] Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan. [15] Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan.;Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Mie University, Tsu, Japan. [16] Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Mie University, Tsu, Japan. [17] Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.;Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.;Folkhalsan Research Center, Helsinki, Finland. [18] Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.;Shenzhen University School of Medicine, Shenzhen, Guangdong, China. [19] Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. [20] Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama City University, Yokohama, Japan. [21] Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.;Department of Integrative Bioanalytics, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. [22] Research Center for Genome & Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.;Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Science, Yokohama, Japan.;RIKEN Preventive Medicine and Diagnosis Innovation Program, Wako, Japan. [23] Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. [24] K.K. DNAFORM, Yokohama, Japan.;RIKEN Preventive Medicine and Diagnosis Innovation Program, Wako, Japan. [25] IFOM ETS - the AIRC Institute of Molecular Oncology, Milan, Italy.;Department of Medical Biotechnology and Translational Medicine, Università degli Studi, Milan, Italy. [26] Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;Human Technopole, Milan, Italy. [27] Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan.;Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. [28] Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.;Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan. [29] RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan.;IFOM ETS - the AIRC Institute of Molecular Oncology, Milan, Italy.;Department of Medical Systems Genomics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. [30]
DOI 10.1126/science.add8394
PMID 38963856
发布时间 2025-04-16
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Science (New York, N.Y.)

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