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首页> Phytomedicine : international journal of phytotherapy and phytopharmacology> Xiaowugui decoction alleviates experimental rheumatoid arthritis by suppressing Rab5a-mediated TLR4 internalization in macrophages.

Xiaowugui decoction alleviates experimental rheumatoid arthritis by suppressing Rab5a-mediated TLR4 internalization in macrophages.

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作者： Feilong,Chen ^[1] ; Dingding,Zhang ^[2] ; Lifang,Cheng ^[3] ; Di,Zhao ^[1] ; Haixin,Ye ^[2] ; Songyuan,Zheng ^[3] ; Qian,Yang ^[3] ; Bingqi,Han ^[2] ; Ran,Wang ^[3] ; Juan,Li ^[4] ; Shixian,Chen ^[5]

作者单位： Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China; Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, PR China. ^[1] Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, PR China. ^[2] Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China. ^[3] Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China; Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, PR China. Electronic address: lijuan@smu.edu.cn. ^[4] Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China. Electronic address: shixian@smu.edu.cn. ^[5]

关键词 Internalization of TLR4 Macrophage Rab5a Rheumatoid arthritis Xiaowugui decoction

主题词动物(Animals);Toll样受体4(Toll-Like Receptor 4);rab5 GTP结合蛋白质类(rab5 GTP-Binding Proteins);小鼠(Mice);人类(Humans);关节炎, 实验性(Arthritis, Experimental);中草药(Drugs, Chinese Herbal);关节炎, 类风湿(Arthritis, Rheumatoid);巨噬细胞(Macrophages);男(雄)性(Male);小鼠, 近交DBA(Mice, Inbred DBA);脂多糖类(Lipopolysaccharides);滑膜(Synovial Membrane);女(雌)性(Female)

DOI 10.1016/j.phymed.2024.155762

PMID 38964156

发布时间 2024-09-27

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