换一批
换一批The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation.
第一作者：
Rainer,Knoll
第一单位：
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
作者：
Rainer,Knoll [1]
;
Elisa T,Helbig [2]
;
Kilian,Dahm [3]
;
Olufemi,Bolaji [4]
;
Frederik,Hamm [5]
;
Oliver,Dietrich [6]
;
Martina,van Uelft [7]
;
Sophie,Müller [8]
;
Lorenzo,Bonaguro [9]
;
Jonas,Schulte-Schrepping [9]
;
Lev,Petrov [4]
;
Benjamin,Krämer [10]
;
Michael,Kraut [11]
;
Paula,Stubbemann [2]
;
Charlotte,Thibeault [12]
;
Sophia,Brumhard [2]
;
Heidi,Theis [11]
;
Gudrun,Hack [10]
;
Elena,De Domenico [11]
;
Jacob,Nattermann [10]
;
Matthias,Becker [1]
;
Marc D,Beyer [13]
;
David,Hillus [2]
;
Philipp,Georg [2]
;
Constantin,Loers [2]
;
Janina,Tiedemann [2]
;
Pinkus,Tober-Lau [2]
;
Lena,Lippert [2]
;
Belén,Millet Pascual-Leone [2]
;
Frank,Tacke [14]
;
Gernot,Rohde [15]
;
Norbert,Suttorp [16]
;
Martin,Witzenrath [16]
;
CAPNETZ Study Group [17]
;
Pa-COVID-19 Study Group [18]
;
Antoine-Emmanuel,Saliba [19]
;
Thomas,Ulas [4]
;
Julia K,Polansky [20]
;
Birgit,Sawitzki [18]
;
Leif E,Sander [21]
;
Joachim L,Schultze [22]
;
Anna C,Aschenbrenner ;
Florian,Kurth
作者单位：
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
[1]
Department of Infectious Diseases and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
[2]
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Translational Pediatrics, Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany.
[3]
Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
[4]
BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
[5]
Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany.
[6]
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Genomics & Immunoregulation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.
[7]
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Genomics & Immunoregulation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
[8]
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; PRECISE Platform for Single Cell Genomics and Epigenomics, DZNE, University of Bonn, and West German Genome Center, Bonn, Germany.
[9]
Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
[10]
PRECISE Platform for Single Cell Genomics and Epigenomics, DZNE, University of Bonn, and West German Genome Center, Bonn, Germany.
[11]
Department of Infectious Diseases and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany; BIH Biomedical Innovation Academy, BIH Charité Clinician Scientist Program, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
[12]
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; PRECISE Platform for Single Cell Genomics and Epigenomics, DZNE, University of Bonn, and West German Genome Center, Bonn, Germany; Immunogenomics & Neurodegeneration, Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
[13]
Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
[14]
Department of Respiratory Medicine, Medical Clinic I, Goethe-Universität Frankfurt am Main, Frankfurt, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany; CAPNETZ STIFTUNG, 30625 Hannover, Germany.
[15]
Department of Infectious Diseases and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany; CAPNETZ STIFTUNG, 30625 Hannover, Germany; German Center for Lung Research (DZL), Germany.
[16]
Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany; Faculty of Medicine, Institute of Molecular Infection Biology (IMIB), University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
[17]
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Genomics & Immunoregulation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany; PRECISE Platform for Single Cell Genomics and Epigenomics, DZNE, University of Bonn, and West German Genome Center, Bonn, Germany.
[18]
BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany; German Rheumatism Research Centre (DRFZ) Berlin, Berlin, Germany.
[19]
Department of Infectious Diseases and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany; BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Germany.
[20]
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany. Electronic address: anna.aschenbrenner@dzne.de.
[21]
Department of Infectious Diseases and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Germany.
[22]
主题词
人类(Humans);地塞米松(Dexamethasone);单核细胞(Monocytes);男(雄)性(Male);单细胞分析(Single-Cell Analysis);女(雌)性(Female);中年人(Middle Aged);老年人(Aged);糖皮质激素类(Glucocorticoids);肺(Lung);成年人(Adult)
DOI
10.1016/j.cell.2024.06.014
PMID
38964327
发布时间
2024-08-09
- 浏览10
Cell
Cell
4318-4335.e20页
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