首页> Clinical and translational medicine> KMT2D-mediated H3K4me1 recruits YBX1 to facilitate triple-negative breast cancer progression through epigenetic activation of c-Myc.

KMT2D-mediated H3K4me1 recruits YBX1 to facilitate triple-negative breast cancer progression through epigenetic activation of c-Myc.

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第一作者： Bing,Yao

第一单位： Department of Medical Genetics, Nanjing Medical University, Nanjing, China.;Department of General Surgery, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China.;Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China.

作者： Bing,Yao ^[1] ; Mengying,Xing ^[2] ; Xiangwei,Zeng ^[3] ; Ming,Zhang ^[2] ; Que,Zheng ^[2] ; Zhi,Wang ^[3] ; Bo,Peng ^[4] ; Shuang,Qu ^[5] ; Lingyun,Li ^[2] ; Yucui,Jin ^[2] ; Haitao,Li ^[4] ; Hongyan,Yuan ^[6] ; Quan,Zhao ^[3] ; Changyan,Ma ^[7]

作者单位： Department of Medical Genetics, Nanjing Medical University, Nanjing, China.;Department of General Surgery, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China.;Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China. ^[1] Department of Medical Genetics, Nanjing Medical University, Nanjing, China. ^[2] The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China. ^[3] MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China. ^[4] School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China. ^[5] Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA. ^[6] Department of Medical Genetics, Nanjing Medical University, Nanjing, China.;Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China. ^[7]

关键词 Y‐box‐binding protein 1 (YBX1)histone H3 lysine 4 mono‐methylation (H3K4me1)lysine methyltransferase 2D (KMT2D)triple‐negative breast cancer (TNBC)