Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice.

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作者： Jennifer,Lee ^[1] ; Kerry,Wellenstein ^[1] ; Ali,Rahnavard ^[2] ; Andrew T,Nelson ^[3] ; Marlena M,Holter ^[4] ; Bethany P,Cummings ^[5] ; Vladimir,Yeliseyev ^[6] ; Angela,Castoldi ^[7] ; Clary B,Clish ^[8] ; Lynn,Bry ^[6] ; Dionicio,Siegel ^[3] ; Barbara B,Kahn ^[1]

作者单位： Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215. ^[1] Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, George Washington University, Washington, DC 20052. ^[2] Division of Pharmaceutical Chemistry, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093. ^[3] Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Cornell University, Ithaca, NY 14850. ^[4] Department of Surgery, School of Medicine, University of California, Davis, Sacramento, CA 95817.;Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis School of Veterinary Medicine, Davis, CA 95616. ^[5] Massachusetts Host-Microbiome Center, Department of Pathology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115. ^[6] Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife 50670-901, Brazil. ^[7] Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142. ^[8]

关键词 Bacteroides thetaiotaomicron PAHSAs diet-induced obesity glucose metabolism gut microbiota