Establishment of a conditionally reprogrammed primary eccrine sweat gland culture for evaluation of tissue-specific CFTR function.

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第一作者： Alice C,Eastman

第一单位： Johns Hopkins School of Medicine, Department of Human Genetics, Miller Research Building, 733N Broadway, Baltimore, MD 21205, USA.

作者： Alice C,Eastman ^[1] ; Gedge,Rosson ^[2] ; Noori,Kim ^[3] ; Sewon,Kang ^[3] ; Karen,Raraigh ^[1] ; Loyal A,Goff ^[1] ; Christian,Merlo ^[4] ; Noah,Lechtzin ^[4] ; Garry R,Cutting ^[1] ; Neeraj,Sharma ^[5]

作者单位： Johns Hopkins School of Medicine, Department of Human Genetics, Miller Research Building, 733N Broadway, Baltimore, MD 21205, USA. ^[1] Johns Hopkins Medicine, Department of Plastic and Reconstructive Surgery, 601N Caroline St, Baltimore, MD 21287, USA. ^[2] Johns Hopkins School of Medicine, Department Medicine, Division of Dermatology, 601N Caroline St, Baltimore, MD 21287, USA. ^[3] Johns Hopkins University School of Medicine, Department of Medicine, Division of Pulmonary and Critical Care Medicine, 1800 Orleans St, Baltimore, MD 21287, USA. ^[4] Johns Hopkins School of Medicine, Department of Human Genetics, Miller Research Building, 733N Broadway, Baltimore, MD 21205, USA. Electronic address: nsharma5@jhmi.edu. ^[5]

关键词 CFTR function Conditional reprogramming Eccrine sweat glands Genotype-phenotype Modulator heterogeneity scRNA-seq

主题词人类(Humans);囊性纤维化跨膜传导调节因子(Cystic Fibrosis Transmembrane Conductance Regulator);囊性纤维化(Cystic Fibrosis);外分泌汗腺(Eccrine Glands);细胞, 培养的(Cells, Cultured);离子转运(Ion Transport)

DOI 10.1016/j.jcf.2024.06.013

PMID 38969603

发布时间 2025-01-04

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