Causal relationship between bone mineral density and intervertebral disc degeneration: a univariate and multivariable mendelian randomization study.

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作者： Luming,Li ^[1] ; Dawei,Li ^[2] ; Ziming,Geng ^[1] ; Zhenxin,Huo ^[2] ; Yuxiang,Kang ^[3] ; Xiangxiang,Guo ^[1] ; Bing,Yuan ^[1] ; Baoshan,Xu ^[4] ; Tao,Wang ^[5]

作者单位： Tianjin Medical University, NO. 22, Qi Xiang Tai Road, Heping District, Tianjin, 300070, China. ^[1] Department of Minimally Invasive Spine Surgery, Tianjin Hospital, No. 406, Jie Fang Nan Road, Hexi District, Tianjin, 300211, China. ^[2] Department of Spine Surgery, Tianjin Hospital, Tianjin University, No. 406 Jiefang South Rd, Hexi District, Tianjin, 300211, China. ^[3] Tianjin TEDA Hospital, No. 61, Third Street, Binhai New Area, Tianjin, 300457, China. ^[4] The Fifth Hospital of Wuhan, The Second Affiliated Hospital of Jianghan University, No. 122 Xianzheng Street, Hanyang District, Wuhan, Hubei, 430050, China. binglive68@163.com. ^[5] Tianjin Medical University, NO. 22, Qi Xiang Tai Road, Heping District, Tianjin, 300070, China. xubaoshan99@126.com. ^[6] Department of Minimally Invasive Spine Surgery, Tianjin Hospital, No. 406, Jie Fang Nan Road, Hexi District, Tianjin, 300211, China. xubaoshan99@126.com. ^[7] Tianjin Medical University, NO. 22, Qi Xiang Tai Road, Heping District, Tianjin, 300070, China. orthospinewangtao@163.com. ^[8] Department of Minimally Invasive Spine Surgery, Tianjin Hospital, No. 406, Jie Fang Nan Road, Hexi District, Tianjin, 300211, China. orthospinewangtao@163.com. ^[9]

关键词 Bone mineral density GWAS data Intervertebral disc degeneration Mendelian randomization (MR)Osteoporosis