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首页> Journal of autoimmunity> Pro-fibrotic effect of the susceptible gene PCSK5 in vascular fibrosis of Takayasu arteritis via TGF-β and SMAD3 signaling pathway activation.

Pro-fibrotic effect of the susceptible gene PCSK5 in vascular fibrosis of Takayasu arteritis via TGF-β and SMAD3 signaling pathway activation.

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作者： Jinghua,Wang ^[1] ; Ying,Sun ^[1] ; Rongyi,Chen ^[1] ; Dan,Meng ^[2] ; Yuanyuan,Wei ^[3] ; Lindi,Jiang ^[4] ; Xiufang,Kong ^[5]

作者单位： Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China. ^[1] Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Department of Rheumatology, Zhongshan Hospital, Fudan University, China. ^[2] Department of Immunology, Shanghai Key Laboratory of Bioactive Small Molecules and State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai, China. ^[3] Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China; Center of Clinical Epidemiology and Evidence-based Medicine, Fudan University, Shanghai, China. Electronic address: zsh-rheum@hotmail.com. ^[4] Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China; Center of Clinical Epidemiology and Evidence-based Medicine, Fudan University, Shanghai, China. Electronic address: kong.xiufang@zs-hospital.sh.cn. ^[5]

关键词 Aortic adventitial fibroblasts Leflunomide PCSK5 TGF-β Takayasu arteritis Vascular fibrosis

主题词成年人(Adult);女(雌)性(Female);人类(Humans);男(雄)性(Male);主动脉(Aorta);成纤维细胞(Fibroblasts);纤维化(Fibrosis);疾病遗传易感性(Genetic Predisposition to Disease);基因型(Genotype);多态性, 单核苷酸(Polymorphism, Single Nucleotide);前蛋白转化酶5(Proprotein Convertase 5);信号传导(Signal Transduction);Smad3蛋白质(Smad3 Protein);Takayasu动脉炎(Takayasu Arteritis);转化生长因子β(Transforming Growth Factor beta)

DOI 10.1016/j.jaut.2024.103277

PMID 38972101

发布时间 2024-12-03

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Journal of autoimmunity

103277页

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