In vitro biotransformation of 3-methylmethcathinone (3-MMC) through incubation with human liver microsomes and cytosol and application to in vivo samples.

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第一作者： Natan,Van Wichelen

第一单位： Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium. Electronic address: natan.vanwichelen@uantwerpen.be.

作者： Natan,Van Wichelen ^[1] ; Andrea,Estévez-Danta ^[2] ; Lidia,Belova ^[3] ; Fatima,den Ouden ^[3] ; Nick,Verougstraete ^[4] ; Maarten,Roggeman ^[3] ; Tim,Boogaerts ^[3] ; Maarten,Quireyns ^[3] ; Rani,Robeyns ^[3] ; Nik,De Brabanter ^[5] ; José Benito,Quintana ^[2] ; Rosario,Rodil ^[2] ; Alexander L N,van Nuijs ^[3] ; Adrian,Covaci ^[3] ; Celine,Gys ^[6]

作者单位： Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium. Electronic address: natan.vanwichelen@uantwerpen.be. ^[1] Aquatic One Health Research Center (ARCUS) & Department of Analytical Chemistry, Nutrition and Food Chemistry, Universidade de Santiago de Compostela, R. Constantino Candeira S/N, IIAA building, Santiago de Compostela 15782, Spain. ^[2] Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium. ^[3] Department of Laboratory Medicine, Ghent University Hospital, Ghent 9000, Belgium. ^[4] Laboratory Medicine, AZ Delta General Hospital, Roeselare 8800, Belgium. ^[5] Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium. Electronic address: celine.gys@uantwerpen.be. ^[6]

关键词 3-methylmethcathinone (3-MMC)Human liver cytosol (HLCYT)Human liver microsomes (HLM)In vitro metabolisation In vivo metabolisation Metaphedrone