Peroxiredoxin 1 inhibits streptozotocin-induced Alzheimer's disease-like pathology in hippocampal neuronal cells via the blocking of Ca<sup>2+</sup>/Calpain/Cdk5-mediated mitochondrial fragmentation.

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第一作者： Junghyung,Park

第一单位： National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.

作者： Junghyung,Park ^[1] ; Jinyoung,Won ^[1] ; Eunyeoung,Yang ^[2] ; Jincheol,Seo ^[1] ; Jiyeon,Cho ^[1] ; Jung Bae,Seong ^[1] ; Hyeon-Gu,Yeo ^[3] ; Keonwoo,Kim ^[4] ; Yu Gyeong,Kim ^[3] ; Minji,Kim ^[5] ; Chang-Yeop,Jeon ^[1] ; Kyung Seob,Lim ^[6] ; Dong-Seok,Lee ^[7] ; Youngjeon,Lee ^[8]

作者单位： National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea. ^[1] National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.;Department of Life Science, University of Seoul, Seoul, Republic of Korea. ^[2] National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.;KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea. ^[3] National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.;School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, Republic of Korea. ^[4] National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.;Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. ^[5] Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea. ^[6] School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, Republic of Korea. lee1@knu.ac.kr. ^[7] National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea. neurosci@kribb.re.kr.;KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea. neurosci@kribb.re.kr. ^[8]

关键词 Alzheimer’s disease (AD)Calpain Mitochondria Oxidative stress Peroxiredoxin 1(Prx1)Streptozotocin