首页> Vaccine> Mammalian cell expressed recombinant trimeric spike protein is a potent vaccine antigen and confers near-complete protection against SARS-CoV-2 infection in Hamster.

Mammalian cell expressed recombinant trimeric spike protein is a potent vaccine antigen and confers near-complete protection against SARS-CoV-2 infection in Hamster.

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第一作者： Jitender

第一单位： Vaccine & Biotherapeutics Research Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India.

作者： Jitender ^[1] ; B,Vikram Kumar ^[1] ; Sneha,Singh ^[1] ; Geetika,Verma ^[1] ; Reetesh,Kumar ^[1] ; Pranaya M,Mishra ^[1] ; Sahil,Kumar ^[1] ; Santhosh K,Nagaraj ^[2] ; Joydeep,Nag ^[2] ; Christy M,Joy ^[2] ; Bhushan,Nikam ^[3] ; Dharmendra,Singh ^[3] ; Pooja ^[1] ; Nidhi,Kalidas ^[1] ; Shubham,Singh ^[1] ; Mumtaz ^[1] ; Ashwani K,Bhardwaj ^[1] ; Dhananjay S,Mankotia ^[1] ; Rajesh P,Ringe ^[1] ; Nimesh,Gupta ^[3] ; Shashank,Tripathi ^[4] ; Ravi P N,Mishra ^[5]

作者单位： Vaccine & Biotherapeutics Research Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India. ^[1] Centre for Infectious Disease Research, Indian Institute of Science, Bengaluru, India. ^[2] National Institute of Immunology, New Delhi, India. ^[3] Centre for Infectious Disease Research, Indian Institute of Science, Bengaluru, India; Microbiology & Cell Biology Department, Indian Institute of Science, Bengaluru, India. ^[4] Vaccine & Biotherapeutics Research Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India. Electronic address: ravi.mishra@imtech.res.in. ^[5]

关键词 ACE2 Adjuvant CHO Hamster Pre-clinical Protein-subunit SARS-CoV-2 Spike Vaccine