SARS-CoV-2 spike protein potentiates platelet aggregation via upregulating integrin αIIbβ3 outside-in signaling pathway.

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作者： Ruijie,Wang ^[1] ; Zezhong,Tian ^[1] ; Meiyan,Zhu ^[2] ; Bingying,Zhang ^[2] ; Yanzhang,Li ^[2] ; Yiqi,Zheng ^[3] ; Yuheng,Mao ^[1] ; Yimin,Zhao ^[1] ; Yan,Yang ^[4]

作者单位： School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Guangdong Province, Shenzhen, China.;Guangdong Engineering Technology Center of Nutrition Transformation, Sun Yat-sen University, Guangdong Province, Shenzhen, China.;Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, Guangdong Province, Guangzhou, China. ^[1] School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Guangdong Province, Shenzhen, China. ^[2] Zhongshan School of Medicine, Sun Yat-sen University, Guangdong Province, Guangzhou, China. ^[3] School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Guangdong Province, Shenzhen, China. yangyan3@mail.sysu.edu.cn.;Guangdong Engineering Technology Center of Nutrition Transformation, Sun Yat-sen University, Guangdong Province, Shenzhen, China. yangyan3@mail.sysu.edu.cn.;Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, Guangdong Province, Guangzhou, China. yangyan3@mail.sysu.edu.cn. ^[4]

关键词 SARS-CoV-2 integrin αIIbβ3 outside-in signaling platelet spike protein

主题词人类(Humans);血小板聚集(Platelet Aggregation);血小板糖蛋白GPⅡb-Ⅲa复合物(Platelet Glycoprotein GPIIb-IIIa Complex);信号传导(Signal Transduction);增量调节(Up-Regulation);血小板(Blood Platelets);磷酰化(Phosphorylation)

DOI 10.1007/s11239-024-03008-8

PMID 38981976

发布时间 2024-10-31

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