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Class B1 GPCRs: insights into multireceptor pharmacology for the treatment of metabolic disease.

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第一作者： Panjamaporn,Sangwung

第一单位： Molecular Pharmacology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States.

作者： Panjamaporn,Sangwung ^[1] ; Joseph D,Ho ^[2] ; Tessa,Siddall ^[3] ; Jerry,Lin ^[3] ; Alejandra,Tomas ^[3] ; Ben,Jones ^[4] ; Kyle W,Sloop ^[5]

作者单位： Molecular Pharmacology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States. ^[1] Department of Structural Biology, Lilly Biotechnology Center, San Diego, California, United States. ^[2] Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom. ^[3] Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom. ^[4] Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States. ^[5]

关键词 glucagon receptor glucagon-like peptide-1 receptor glucose-dependent insulinotropic polypeptide receptor obesity type 2 diabetes

医学主题词人类(Humans);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);动物(Animals);代谢疾病(Metabolic Diseases);受体, 胃肠激素(Receptors, Gastrointestinal Hormone);配体(Ligands);糖尿病, 2型(Diabetes Mellitus, Type 2)

DOI 10.1152/ajpendo.00371.2023

PMID 38984948

发布时间 2026-05-19

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