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Jiawei Duhuo Jisheng Mixture Mitigates Osteoarthritis Progression in Rabbits by Inhibiting Inflammation: A Network Pharmacology and Experimental Approach.

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第一作者： Tan,Kaiyun

第一单位： Department of Orthopedic Surgery, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China.;Integrated Chinese and Western Medicine College, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China.

作者： Tan,Kaiyun ^[1] ; Xu,Xiaotong ^[2] ; Lu,Min ^[2] ; Wu,Yongrong ^[3] ; Tan,Xuyi ^[4] ; Shen,Fu ^[5] ; Ge,Jinwen ^[6] ; Kuang,Gaoyan ^[2]

作者单位： Department of Orthopedic Surgery, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China.;Integrated Chinese and Western Medicine College, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China. ^[1] Department of Orthopedic Surgery, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China. ^[2] Integrated Chinese and Western Medicine College, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China. ^[3] Department of Orthopedic Surgery, The Affiliated Hospital of Hunan Provincial Research Institute of Traditional Chinese Medicine, Changsha, 410006, China. ^[4] Department of Orthopedic Surgery, Yongzhou Hospital of Traditional Chinese Medicine, Yongzhou, 425000, China. ^[5] Integrated Chinese and Western Medicine College, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China.;Hunan Provincial Research Institute of Traditional Chinese Medicine, Changsha, 410006, China. ^[6]

关键词 ELISA IL- 6 Inflammation Jiawei Duhuo Jisheng Mixture (JDJM)Knee osteoarthritis Molecular docking Molecular dynamics simulation Network pharmacology Pharmacokinetics.TNF-α Traditional Chinese Medicine Weighted gene coexpression network analysis