Instrumental variable and colocalization analyses identify endotrophin and HTRA1 as potential therapeutic targets for coronary artery disease.

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第一作者： Paul C,Lee

第一单位： Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.

作者： Paul C,Lee ^[1] ; In-Hyuk,Jung ^[1] ; Shreeya,Thussu ^[1] ; Ved,Patel ^[1] ; Ryan,Wagoner ^[1] ; Kendall H,Burks ^[1] ; Junedh,Amrute ^[1] ; Jared S,Elenbaas ^[1] ; Chul Joo,Kang ^[2] ; Erica P,Young ^[3] ; Philipp E,Scherer ^[4] ; Nathan O,Stitziel ^[5]

作者单位： Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA. ^[1] McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO 63108, USA. ^[2] Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.;McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO 63108, USA. ^[3] Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. ^[4] Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.;McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO 63108, USA.;Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA. ^[5]

关键词 Association analysis Biocomputational method Cardiovascular medicine Quantitative genetics Techniques in genetics

DOI 10.1016/j.isci.2024.110104

PMID 38989470

发布时间 2024-08-07

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Instrumental variable and colocalization analyses identify endotrophin and HTRA1 as potential therapeutic targets for coronary artery disease.

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Instrumental variable and colocalization analyses identify endotrophin and HTRA1 as potential therapeutic targets for coronary artery disease.

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