Sugar and arginine facilitate oral tolerance by ensuring the functionality of tolerogenic immune cell subsets in the intestine.

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第一作者： Motoyoshi,Nagai

第一单位： Clinical Research Advancement Section, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan. Electronic address: motoyoshin@keio.jp.

作者： Motoyoshi,Nagai ^[1] ; Takuma,Okawa ^[2] ; Kazuaki,Nakata ^[3] ; Daisuke,Takahashi ^[2] ; Reina,Miyajima ^[2] ; Hiroaki,Shiratori ^[2] ; Daisuke,Yamanaka ^[4] ; Atsuo,Nakamura ^[5] ; Chinatsu,Oyama ^[6] ; Shin-Ichiro,Takahashi ^[7] ; Noriko,Toyama-Sorimachi ^[8] ; Koichiro,Suzuki ^[2] ; Wakana,Ohashi ^[2] ; Taeko,Dohi ^[9] ; Yuki I,Kawamura ^[3] ; Koji,Hase ^[10]

作者单位： Clinical Research Advancement Section, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan. Electronic address: motoyoshin@keio.jp. ^[1] Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan. ^[2] Clinical Research Advancement Section, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan. ^[3] Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan. ^[4] Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan; Dairy Science and Technology Institute, Kyodo Milk Industry Co., Hinode-machi, Nishitama-gun, Tokyo, Japan. ^[5] Communal Laboratory, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan. ^[6] Departments of Animal Sciences and Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan. ^[7] Division of Human Immunology, International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo (IMSUT), Tokyo, Japan. ^[8] Clinical Research Advancement Section, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan. ^[9] Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan; The Institute of Fermentation Sciences (IFeS), Faculty of Food and Agricultural Sciences, Fukushima University, Kanayagawa, Fukushima 960-1296, Japan; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo (IMSUT), Tokyo 108-8639, Japan. Electronic address: hase.a6@keio.jp. ^[10]

关键词 CP: Immunology CP: Metabolism CX3CR1(+) cells allergy dendritic cells fasting food antigens mTOR signaling metabolic rewiring nutrition oral tolerance regulatory T cells