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FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis.

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作者单位: School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. [1] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.;Department of Gastroenterology, Center for Fatty Liver, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, Shanghai, 200092, China. [2] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.;Xiangya Hospital, Central South University, Changsha, 410013, China. [3] School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210029, China. [4] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.;University of the Chinese Academy of Sciences, Beijing, 100049, China. [5] Cascade Pharmaceuticals, Inc, Shanghai, 201321, China. [6] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.;Department of Laboratory Medicine and Central Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, China. [7] Industrial Technology Research Institute of Pharmacy, Guilin Medical University, Guilin, 541199, China. [8] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. yameng_liu@simm.ac.cn. [9] Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. [10] Department of Gastroenterology, Center for Fatty Liver, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, Shanghai, 200092, China. fanjiangao@xinhuamed.com.cn. [11] School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. xiecen@simm.ac.cn.;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. xiecen@simm.ac.cn.;School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210029, China. xiecen@simm.ac.cn.;University of the Chinese Academy of Sciences, Beijing, 100049, China. xiecen@simm.ac.cn. [12]
DOI 10.1038/s41401-024-01329-1
PMID 38992119
发布时间 2024-10-25
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Acta pharmacologica Sinica

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