Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE<sub>2</sub> production.

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作者： Xilong,Xu ^[1] ; Yi,Lu ^[2] ; Longzhi,Cao ^[3] ; Yang,Miao ^[4] ; Yamei,Li ^[3] ; Yue,Cui ^[1] ; Ting,Han ^[5]

作者单位： College of Life Sciences, Beijing Normal University, Beijing 100875, China; National Institute of Biological Sciences, Beijing 102206, China. ^[1] National Institute of Biological Sciences, Beijing 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China. ^[2] National Institute of Biological Sciences, Beijing 102206, China; Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China. ^[3] National Institute of Biological Sciences, Beijing 102206, China; PTN Joint Graduate Program, School of Life Sciences, Tsinghua University, Beijing 100084, China. ^[4] College of Life Sciences, Beijing Normal University, Beijing 100875, China; National Institute of Biological Sciences, Beijing 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China. Electronic address: hanting@nibs.ac.cn. ^[5]

关键词 CP: Cancer CP: Immunology P2RY6 immunotherapy resistance prostaglandin E2 tumor microenvironment tumor?immune evasion