Modulation of AAV9 Galactose Binding Yields Novel Gene Therapy Vectors and Predicts Cross-Species Differences in Glycan Avidity.

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第一作者： Jacob A,Hoffman

第一单位： Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

作者： Jacob A,Hoffman ^[1] ; Nathan,Denton ^[1] ; Joshua J,Sims ^[1] ; Rosemary,Meggersee ^[1] ; Zhe,Zhang ^[1] ; Kanyin,Olagbegi ^[1] ; James M,Wilson ^[1]

作者单位： Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[1]

关键词 adeno-associated virus (AAV)glycan glycomics nonhuman primate (NHP)transduction translational

主题词依赖病毒(Dependovirus);动物(Animals);遗传载体(Genetic Vectors);半乳糖(Galactose);小鼠(Mice);多糖类(Polysaccharides);人类(Humans);肝(Liver);衣壳蛋白质类(Capsid Proteins);种特异性(Species Specificity);转导, 遗传(Transduction, Genetic)

DOI 10.1089/hum.2024.050

PMID 39001819

发布时间 2024-11-12

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Human gene therapy

2024年35卷17-18期

734-753页

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Modulation of AAV9 Galactose Binding Yields Novel Gene Therapy Vectors and Predicts Cross-Species Differences in Glycan Avidity.

Human gene therapy

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Modulation of AAV9 Galactose Binding Yields Novel Gene Therapy Vectors and Predicts Cross-Species Differences in Glycan Avidity.

Human gene therapy

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Human gene therapy

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