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Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy.

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第一作者： Hui,Zhong

第一单位： Wuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Chinese Academy of Sciences, ,; Hubei Clinical Research Center for Infectious Diseases, ,; Wuhan Research Center for Communicable Disease Diagnosis and Treatment, Chinese Academy of Medical Sciences, ,; Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Chinese Academy of Sciences,.

作者： Hui,Zhong ^[1] ; Tianshu,Liu ^[2] ; You,Shang ^[3] ; Chaolin,Huang ^[4] ; Shangwen,Pan ^[5]

作者单位： Wuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Chinese Academy of Sciences, ,; Hubei Clinical Research Center for Infectious Diseases, ,; Wuhan Research Center for Communicable Disease Diagnosis and Treatment, Chinese Academy of Medical Sciences, ,; Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Chinese Academy of Sciences,. ^[1] Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,. ^[2] Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,. ^[3] Wuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Chinese Academy of Sciences, ,; Hubei Clinical Research Center for Infectious Diseases, ,; Wuhan Research Center for Communicable Disease Diagnosis and Treatment, Chinese Academy of Medical Sciences, ,; Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Chinese Academy of Sciences, ,. Electronic address: 2020jy0003@hust.edu.cn. ^[4] Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, ,. Electronic address: pan_shangwen@163.com. ^[5]

关键词 Microglia NLRP3 inflammasome Negative regulation Sepsis-associated encephalopathy

医学主题词人类(Humans);炎性体(Inflammasomes);动物(Animals);小神经胶质细胞(Microglia);血脑屏障(Blood-Brain Barrier)

DOI 10.1016/j.biopha.2024.117042

PMID 39004064

发布时间 2024-07-27

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