Time- and Region-specific Effect of Vortioxetine on Central LPS-induced Transcriptional Regulation of NLRP3 Inflammasome.

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作者： Miriam,Ciani ^[1] ; Giovanna,Rigillo ^[2] ; Cristina,Benatti ^[2] ; Luca,Pani ^[3] ; Johanna M C,Blom ^[2] ; Nicoletta,Brunello ^[1] ; Fabio,Tascedda ^[4] ; Silvia,Alboni ^[5]

作者单位： Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy. ^[1] Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.;Centre of Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy. ^[2] Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.;Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, USA. ^[3] Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.;Centre of Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy.;CIB, Consorzio Interuniversitario Biotecnologie, Trieste, Italy. ^[4] Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.;Centre of Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy. ^[5]

关键词 Depression NLRP3 inflammasome cognitive impairment frontalprefrontal cortex hippocampus hypothalamus.neuroinflammation vortioxetine