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Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology.

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第一作者： Camila,de Ávila

第一单位： Arizona State University-Banner Neurodegenerative Disease Research Center, Tempe, AZ, USA. cdeavila@asu.edu.

作者： Camila,de Ávila ^[1] ; Anna,Gugula ^[2] ; Aleksandra,Trenk ^[2] ; Anthony J,Intorcia ^[3] ; Crystal,Suazo ^[4] ; Jennifer,Nolz ^[4] ; Julie,Plamondon ^[5] ; Divyanshi,Khatri ^[4] ; Lauren,Tallant ^[6] ; Alexandre,Caron ^[7] ; Anna,Blasiak ^[2] ; Geidy E,Serrano ^[3] ; Thomas G,Beach ^[3] ; Andrew L,Gundlach ^[8] ; Diego F,Mastroeni ^[9]

作者单位： Arizona State University-Banner Neurodegenerative Disease Research Center, Tempe, AZ, USA. cdeavila@asu.edu. ^[1] Department of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland. ^[2] Arizona Alzheimer's Consortium, Phoenix, AZ, USA.;Banner Sun Health Research Institute, Sun City, AZ, USA. ^[3] Arizona State University-Banner Neurodegenerative Disease Research Center, Tempe, AZ, USA. ^[4] Quebec Heart and Lung Institute, Quebec City, QC, Canada. ^[5] Department of Neuroscience, Mayo Clinic, Scottsdale, AZ, USA. ^[6] Quebec Heart and Lung Institute, Quebec City, QC, Canada.;Faculty of Pharmacy, Université Laval, Quebec City, QC, Canada. ^[7] Florey Department of Neuroscience and Mental Health and Department of Anatomy and Physiology and The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia. ^[8] Arizona State University-Banner Neurodegenerative Disease Research Center, Tempe, AZ, USA.;Arizona Alzheimer's Consortium, Phoenix, AZ, USA. ^[9]

关键词 Brainstem Dementia Hippocampus Human Memory Nucleus incertus Relaxin-3

医学主题词人类(Humans);脑桥(Pons);男(雄)性(Male);海马(Hippocampus);女(雌)性(Female);松弛素(Relaxin);老年人(Aged);神经元(Neurons);记忆(Memory);微管相关蛋白质类(Microtubule-Associated Proteins);中年人(Middle Aged);老年人, 80以上(Aged, 80 and over);免疫组织化学(Immunohistochemistry);原位杂交, 荧光(In Situ Hybridization, Fluorescence);谷氨酸脱羧酶(Glutamate Decarboxylase);受体, 促肾上腺皮质素释放激素(Receptors, Corticotropin-Releasing Hormone)

DOI 10.1186/s40659-024-00523-z

PMID 39014514

发布时间 2025-07-20

基金项目

P30 AG19610 Arizona Alzheimer's Disease Core Center/AG/NIA NIH HHS/United States contracts 4001/Arizona Biomedical Research Commission contract 211002/Arizona Department of Health Services U24 NS072026 National Brain/NS/NINDS NIH HHS/United States 05-901/Arizona Biomedical Research Commission Tissue Resource for Parkinson's Disease/NS/NINDS NIH HHS/United States Arizona Alzheimer's Research Center/Arizona Department of Health Services A2021006/BrightFocus Foundation 1001 to the Arizona Parkinson's Disease Consortium/Arizona Biomedical Research Commission AARFD-22-972099/ALZ/Alzheimer's Association/United States Related Disorders/NS/NINDS NIH HHS/United States Minigrant at the Faculty of Biology 2023/Strategic Program Initiative of Excellence in the Jagiellonian University U24 NS072026/NS/NINDS NIH HHS/United States P30 AG019610/AG/NIA NIH HHS/United States 0011/Arizona Biomedical Research Commission

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