Multiple Exposures to Sevoflurane General Anesthesia During Pregnancy Inhibit CaMKII/CREB Axis by Downregulating HCN2 to Induce an Autism-Like Phenotype in Offspring Mice.
作者:
主题词
动物(Animals);小鼠(Mice);妊娠(Pregnancy);女(雌)性(Female);钙-钙调素依赖性蛋白激酶2型(Calcium-Calmodulin-Dependent Protein Kinase Type 2);产前暴露迟发效应(Prenatal Exposure Delayed Effects);麻醉药, 吸入(Anesthetics, Inhalation);减量调节(Down-Regulation);孤独性障碍(Autistic Disorder);cAMP反应元件结合蛋白质(Cyclic AMP Response Element-Binding Protein);钾通道(Potassium Channels);细胞, 培养的(Cells, Cultured);神经元(Neurons);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL)
DOI
10.1007/s12031-024-02243-1
PMID
39017898
发布时间
2024-10-04
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