Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution.

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作者： Michelle,Dietzen ^[1] ; Haoran,Zhai ^[2] ; Olivia,Lucas ^[3] ; Oriol,Pich ^[2] ; Christopher,Barrington ^[4] ; Wei-Ting,Lu ^[5] ; Sophia,Ward ^[6] ; Yanping,Guo ^[7] ; Robert E,Hynds ^[2] ; Simone,Zaccaria ^[8] ; Charles,Swanton ^[9] ; Nicholas,McGranahan ^[10] ; Nnennaya,Kanu ^[11]

作者单位： Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.;Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.;Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. ^[1] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.;Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. ^[2] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.;Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.;Computational Cancer Genomics Research Group, University College London Cancer Institute, London, UK.;Department of Oncology, University College London Hospitals, London, UK. ^[3] Bioinformatics and Biostatistics Science Technology Platform, The Francis Crick Institute, London, UK. ^[4] Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. ^[5] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.;Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.;Advanced Sequencing Facility, The Francis Crick Institute, London, UK. ^[6] CRUK Flow Cytometry Translational Technology Platform, UCL Cancer Institute, London, UK. ^[7] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.;Computational Cancer Genomics Research Group, University College London Cancer Institute, London, UK. ^[8] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.;Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.;Department of Oncology, University College London Hospitals, London, UK. ^[9] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.;Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk. ^[10] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. n.kanu@ucl.ac.uk.;Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. n.kanu@ucl.ac.uk. ^[11]