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Elucidating the mechano-molecular dynamics of TRAP activity using CRISPR/Cas9 mediated fluorescent reporter mice.

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第一作者： Dilara,Yılmaz

第一单位： Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.

作者： Dilara,Yılmaz ^[1] ; Francisco C,Marques ^[1] ; Yannick,Fischer ^[1] ; Sandra,Zimmermann ^[1] ; Gaonhae,Hwang ^[1] ; Penny R,Atkins ^[2] ; Neashan,Mathavan ^[1] ; Amit,Singh ^[1] ; Pedro P C,de Souza ^[3] ; Gisela A,Kuhn ^[1] ; Esther,Wehrle ^[4] ; Ralph,Müller ^[1]

作者单位： Institute for Biomechanics, ETH Zürich, Zürich, Switzerland. ^[1] Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.;Department of Orthopaedics, University of Utah, 590 Wakara Way, Salt Lake City, USA. ^[2] Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.;Innovation in Biomaterials Laboratory, School of Dentistry, Federal University of Goiás, Goiânia, Brazil. ^[3] Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.;AO Research Institute Davos, Davos Platz, Switzerland. ^[4]

关键词 Bone remodeling CRISPR/Cas9 mediated reporter mice Fluorescent osteoclasts and osteoblasts In vivo loading Mechanosensitivity Micro-computed tomography Micro-finite element analysis TRAP deficiency Trabecular bone remodeling

DOI 10.1016/j.heliyon.2024.e32949

PMID 39021958

发布时间 2024-07-19

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