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Integrated transcriptomics of human blood vessels defines a spatially controlled niche for early mesenchymal progenitor cells.

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第一作者： Yiyun,Wang

第一单位： Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.

作者： Yiyun,Wang ^[1] ; Neelima,Thottappillil ^[1] ; Mario,Gomez-Salazar ^[1] ; Robert J,Tower ^[2] ; Qizhi,Qin ^[1] ; Ishbel Camila,Del Rosario Alvia ^[1] ; Mingxin,Xu ^[1] ; Masnsen,Cherief ^[1] ; Ray,Cheng ^[1] ; Mary,Archer ^[1] ; Shreya,Arondekar ^[1] ; Sashank,Reddy ^[3] ; Kristen,Broderick ^[3] ; Bruno,Péault ^[4] ; Aaron W,James ^[5]

作者单位： Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA. ^[1] Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ^[2] Department of Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD 21205, USA. ^[3] Department of Orthopedic Surgery and Orthopedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA. ^[4] Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: awjames@jhmi.edu. ^[5]

关键词 blood vessel mesenchymal stem/progenitor cells ossicle formation perivascular spatial transcriptomics stem cell niche tunica adventitia

医学主题词人类(Humans);间质干细胞(Mesenchymal Stem Cells);干细胞壁龛(Stem Cell Niche);动物(Animals);小鼠(Mice);血管(Blood Vessels);骨生成(Osteogenesis);细胞分化(Cell Differentiation);细胞增殖(Cell Proliferation)

DOI 10.1016/j.devcel.2024.06.015

PMID 39025061

发布时间 2025-10-22

基金项目

R21 AR078919/AR/NIAMS NIH HHS/United States R01 DE031028/DE/NIDCR NIH HHS/United States P01 AG066603/AG/NIA NIH HHS/United States R01 AR079171/AR/NIAMS NIH HHS/United States R01 DE031488/DE/NIDCR NIH HHS/United States

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