Toxicological evidence integration to confirm the biological plausibility of the association between humidifier disinfectant exposure and respiratory diseases using the AEP-AOP framework.

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作者： Ha Ryong,Kim ^[1] ; Jun Woo,Kim ^[2] ; Jong-Hyeon,Lee ^[3] ; Younghee,Kim ^[4] ; Jungyun,Lim ^[4] ; Yong-Wook,Baek ^[4] ; Sunkyoung,Shin ^[4] ; Mina,Ha ^[5] ; Hae-Kwan,Cheong ^[6] ; Kyu Hyuck,Chung ^[7] ; Review Committee for the Epidemiological Correlations between Humidifier Disinfectants Exposure and Health Effects

作者单位： Korea University College of Pharmacy, Sejong, Korea. ^[1] Sungkyunkwan University, School of Pharmacy, Suwon, Korea. ^[2] EH R&C Co., Incheon, Korea. ^[3] Humidifier Disinfectant Health Center, Environmental Health Research Department, National Institute of Environmental Research, Incheon, Korea. ^[4] Dankook University College of Medicine, Cheonan, Korea. ^[5] Sungkyunkwan University, School of Medicine, Suwon, Korea. ^[6] Sungkyunkwan University, School of Pharmacy, Suwon, Korea.;Kyungsung University College of Pharmacy, Busan, Korea. ^[7]

关键词 Adverse outcome pathway Aggregate exposure pathway Biological plausibility Evidence-based toxicology Humidifier disinfectants Respiratory diseases

主题词消毒药(剂)(Disinfectants);人类(Humans);胍类(Guanidines);呼吸道疾病(Respiratory Tract Diseases);噻唑类(Thiazoles);动物(Animals);双胍类(Biguanides)

DOI 10.4178/epih.e2024060

PMID 39026433

发布时间 2025-02-12

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