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Deletion of V483 in the spike confers evolutionary advantage on SARS-CoV-2 for human adaptation and host-range expansion after a prolonged pandemic.

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作者: Can,Yue [1] ; Shuo,Liu [2] ; Bo,Meng [3] ; Kaiyue,Fan [4] ; Sijie,Yang [5] ; Pan,Liu [4] ; Qianhui,Zhu [4] ; Xin,Mao [1] ; Yuanling,Yu [6] ; Fei,Shao [6] ; Peng,Wang [6] ; Youchun,Wang [7] ; Ravindra Kumar,Gupta [8] ; Yunlong,Cao [9] ; Xiangxi,Wang [10]
作者单位: CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. [1] Changping Laboratory, Beijing, China.;Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. [2] Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK. bm432@cam.ac.uk. [3] CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China. [4] Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China.;Joint Graduate Program of Peking-Tsinghua-NIBS, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. [5] Changping Laboratory, Beijing, China. [6] Changping Laboratory, Beijing, China. wangyc@nifdc.org.cn.;Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. wangyc@nifdc.org.cn. [7] Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK. rkg20@cam.ac.uk. [8] Changping Laboratory, Beijing, China. yunlongcao@pku.edu.cn.;Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China. yunlongcao@pku.edu.cn.;Joint Graduate Program of Peking-Tsinghua-NIBS, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. yunlongcao@pku.edu.cn. [9] CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. xiangxi@ibp.ac.cn.;Changping Laboratory, Beijing, China. xiangxi@ibp.ac.cn.;University of Chinese Academy of Sciences, Beijing, China. xiangxi@ibp.ac.cn. [10]
DOI 10.1038/s41422-024-01000-8
PMID 39030295
发布时间 2024-10-03
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