Structural characterization and bioactivity profiling of the fungal peptaibiotic tolypin reveal protective effects against influenza viruses.

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第一作者： Johanna,Eichberg

第一单位： Branch for Bioresources of the Fraunhofer IME, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Giessen, Germany.;BMBF Junior Research Group in Infection Research "ASCRIBE", Giessen, Germany.

作者： Johanna,Eichberg ^[1] ; Markus,Oberpaul ^[1] ; Christoph,Hartwig ^[2] ; Andrea Helga,Geißler ^[3] ; Carsten,Culmsee ^[4] ; Andreas,Vilcinskas ^[5] ; Eva,Böttcher-Friebertshäuser ^[6] ; Hans,Brückner ^[7] ; Thomas,Degenkolb ^[3] ; Kornelia,Hardes ^[8]

作者单位： Branch for Bioresources of the Fraunhofer IME, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Giessen, Germany.;BMBF Junior Research Group in Infection Research "ASCRIBE", Giessen, Germany. ^[1] Branch for Bioresources of the Fraunhofer IME, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Giessen, Germany. ^[2] Department of Insect Biotechnology, Justus-Liebig-University of Giessen, Giessen, Germany. ^[3] Institute for Pharmacology and Clinical Pharmacy, Biochemical-Pharmacological Center Marburg, University of Marburg, Marburg, Germany. ^[4] Branch for Bioresources of the Fraunhofer IME, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Giessen, Germany.;Department of Insect Biotechnology, Justus-Liebig-University of Giessen, Giessen, Germany.;LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG), Frankfurt, Germany. ^[5] Institute of Virology, University of Marburg, Marburg, Germany. ^[6] Department of Food Sciences, Interdisciplinary Research Centre for Biosystems, Land Use and Nutrition, Justus-Liebig-University of Giessen, Giessen, Germany. ^[7] Branch for Bioresources of the Fraunhofer IME, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Giessen, Germany.;BMBF Junior Research Group in Infection Research "ASCRIBE", Giessen, Germany.;LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG), Frankfurt, Germany. ^[8]

关键词 Tolypocladium UHPLC‐HR‐MS/MS cellular energy metabolism influenza virus microheterogeneity