HBcrAg values may predict virological and immunological responses to pegIFN-α in NUC-suppressed HBeAg-negative chronic hepatitis B.

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第一作者： Andrea,Vecchi

第一单位： Unit of Infectious Diseases and Hepatology, University Hospital of Parma, Parma, Italy.

作者： Andrea,Vecchi ^[1] ; Marzia,Rossi ^[2] ; Camilla,Tiezzi ^[2] ; Paola,Fisicaro ^[1] ; Sara,Doselli ^[1] ; Elena Adelina,Gabor ^[2] ; Amalia,Penna ^[1] ; Ilaria,Montali ^[2] ; Camilla,Ceccatelli Berti ^[2] ; Valentina,Reverberi ^[2] ; Anna,Montali ^[2] ; Simon P,Fletcher ^[3] ; Elisabetta,Degasperi ^[4] ; Dana,Sambarino ^[4] ; Diletta,Laccabue ^[2] ; Floriana,Facchetti ^[4] ; Simona,Schivazappa ^[1] ; Elisabetta,Loggi ^[5] ; Barbara,Coco ^[6] ; Daniela,Cavallone ^[6] ; Elena,Rosselli Del Turco ^[7] ; Marco,Massari ^[8] ; Giuseppe,Pedrazzi ^[9] ; Gabriele,Missale ^[10] ; Gabriella,Verucchi ^[7] ; Pietro,Andreone ^[5] ; Maurizia Rossana,Brunetto ^[11] ; Pietro,Lampertico ^[12] ; Carlo,Ferrari ^[10] ; Carolina,Boni ^[13]

作者单位： Unit of Infectious Diseases and Hepatology, University Hospital of Parma, Parma, Italy. ^[1] Department of Medicine and Surgery, University of Parma, Parma, Italy. ^[2] Department of Biology, Gilead Sciences, Foster City, California, USA. ^[3] Division of Gastroenterology and Hepatology, IRCCS Foundation Maggiore Policlinico Hospital, Milan, Italy. ^[4] Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy. ^[5] Hepatology Unit, Pisa University Hospital, Pisa, Italy. ^[6] Department of Infectious Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico di Sant'Orsola, Bologna, Italy. ^[7] Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy. ^[8] Department of Medicine and Surgery, Unit of Neuroscience, Interdepartmental Center of Robust Statistics (Ro.S.A.), University of Parma, Parma, Italy. ^[9] Unit of Infectious Diseases and Hepatology, University Hospital of Parma, Parma, Italy.;Department of Medicine and Surgery, University of Parma, Parma, Italy. ^[10] Hepatology Unit, Pisa University Hospital, Pisa, Italy.;Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy. ^[11] Division of Gastroenterology and Hepatology, IRCCS Foundation Maggiore Policlinico Hospital, Milan, Italy.;CRC "A. M. and A. Migliavacca" Center for Liver Disease, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. ^[12] Unit of Infectious Diseases and Hepatology, University Hospital of Parma, Parma, Italy carolina.boni@unipr.it.;Department of Medicine and Surgery, University of Parma, Parma, Italy. ^[13]

关键词 Chronic HBV infection HBcrAg HBsAg T cell functional reconstitution immune modulatory treatments pegylated IFN-a