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Refining the optimal CAF cluster marker for predicting TME-dependent survival expectancy and treatment benefits in NSCLC patients.

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第一作者： Kai,Li

第一单位： Department of Otorhinolaryngology‑Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.

作者： Kai,Li ^[1] ; Rui,Wang ^[2] ; Guo-Wei,Liu ^[3] ; Zi-Yang,Peng ^[4] ; Ji-Chang,Wang ^[5] ; Guo-Dong,Xiao ^[6] ; Shou-Ching,Tang ^[7] ; Ning,Du ^[2] ; Jia,Zhang ^[2] ; Jing,Zhang ^[2] ; Hong,Ren ^[2] ; Xin,Sun ^[8] ; Yi-Ping,Yang ^[9] ; Da-Peng,Liu ^[10]

作者单位： Department of Otorhinolaryngology‑Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. ^[1] Department of Thoracic Surgery and Oncology, Cancer Centre, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China. ^[2] Department of Thoracic Surgery, Qinghai Provincial People's Hospital, Gonghe Road No. 2, Chengdong District, Xining, 810007, Qinghai, China. ^[3] School of Future Technology, National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. ^[4] Department of Vascular Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. ^[5] Oncology Department, The First Affiliated Hospital of Zhengzhou University, Zheng Zhou, 450052, Henan, China. ^[6] Section of Hematology Oncology, Department of Internal Medicine, LSUHSC Cancer Center, School of Medicine, 1700 Tulane Avenue, New Orleans, LA, 70112, USA. ^[7] Department of Thoracic Surgery and Oncology, Cancer Centre, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China.;Department of Pathology, Anatomy and Cell Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA. ^[8] Department of Radiotherapy, Shaanxi Provincial Tumor Hospital, 309 Yanta W Rd, Yanta District, Xi'an, 710063, Shaanxi, China. yangyiping1029@163.com. ^[9] Department of Thoracic Surgery and Oncology, Cancer Centre, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China. prof_ldp_oncology@126.com. ^[10]

关键词 Cancer associated fibroblasts Marker selection Therapy response Tumor microenvironment scRNA sequence data

医学主题词人类(Humans);肺肿瘤(Lung Neoplasms);肿瘤微环境(Tumor Microenvironment);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);预后(Prognosis);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic)

DOI 10.1038/s41598-024-55375-0

PMID 39034310

发布时间 2024-08-05

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