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RYR2 deficient human model identifies calcium handling and metabolic dysfunction impacting pharmacological responses.

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第一作者： Linda,Starnes

第一单位： Safety Sciences, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.

作者： Linda,Starnes ^[1] ; Andrew,Hall ^[2] ; Damla,Etal ^[3] ; Anna-Lina,Cavallo ^[3] ; Piotr,Grabowski ^[4] ; John,Gallon ^[4] ; Michelle,Kha ^[1] ; Ryan,Hicks ^[5] ; Amy,Pointon ^[2]

作者单位： Safety Sciences, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden. ^[1] Safety Sciences, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom. ^[2] Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden. ^[3] Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom. ^[4] BioPharmaceuticals R&D Cell Therapy Department, Research and Early Development, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.;School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, United Kingdom. ^[5]

关键词 calcium handling cardiovascular in vitro models heart failure hiPSC-CMs pentose phosphate pathway ryanodine receptor 2

DOI 10.3389/fcvm.2024.1357315

PMID 39041002

发布时间 2024-07-24

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RYR2 deficient human model identifies calcium handling and metabolic dysfunction impacting pharmacological responses.

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RYR2 deficient human model identifies calcium handling and metabolic dysfunction impacting pharmacological responses.

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