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首页> Proceedings of the National Academy of Sciences of the United States of America> Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.

Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.

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作者： Barbara,Celona ^[1] ; Sally E,Salomonsson ^[2] ; Haifan,Wu ^[3] ; Bobo,Dang ^[3] ; Huong T,Kratochvil ^[3] ; Claire D,Clelland ^[2] ; William F,DeGrado ^[3] ; Brian L,Black ^[4]

作者单位： Cardiovascular Research Institute, University of California, San Francisco, CA 94143. ^[1] Weill Institute for Neurosciences, University of California, San Francisco, CA 94143.;Memory & Aging Center, Department of Neurology, University of California, San Francisco, CA 94143. ^[2] Cardiovascular Research Institute, University of California, San Francisco, CA 94143.;Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143. ^[3] Cardiovascular Research Institute, University of California, San Francisco, CA 94143.;Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143. ^[4]

关键词 C9orf72 G-quadruplex RAN translation RNA-binding protein amyotrophic lateral sclerosis

主题词动物(Animals);人类(Humans);小鼠(Mice);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);DNA重复序列扩增(DNA Repeat Expansion);额颞叶痴呆(Frontotemporal Dementia);G四链体(G-Quadruplexes);神经组织蛋白质类(Nerve Tissue Proteins);蛋白质结合(Protein Binding);蛋白质生物合成(Protein Biosynthesis);RNA(RNA);RNA结合蛋白质类(RNA-Binding Proteins)

DOI 10.1073/pnas.2220020121

PMID 39042693

发布时间 2025-01-24

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

2024年121卷31期

e2220020121页

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Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

2024年121卷31期

e2220020121页

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