Targeting the glucocorticoid receptor-CCR8 axis mediated bone marrow T cell sequestration enhances infiltration of anti-tumor T cells in intracranial cancers.

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第一作者： Jia,Zhang

第一单位： The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Soochow University Suzhou Medical College, Suzhou, Jiangsu, China.

作者： Jia,Zhang ^[1] ; Yuzhu,Shi ^[1] ; Xiaotong,Xue ^[1] ; Wenqing,Bu ^[1] ; Yanan,Li ^[1] ; Tingting,Yang ^[1] ; Lijuan,Cao ^[2] ; Jiankai,Fang ^[1] ; Peishan,Li ^[1] ; Yongjing,Chen ^[1] ; Zhen,Li ^[3] ; Changshun,Shao ^[4] ; Yufang,Shi ^[5]

作者单位： The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Soochow University Suzhou Medical College, Suzhou, Jiangsu, China. ^[1] The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Soochow University Suzhou Medical College, Suzhou, Jiangsu, China.;Department of Experimental Medicine and Biochemical Sciences, TOR, University of Rome "Tor Vergata", Rome, Italy. ^[2] Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, Jiangsu, China. ^[3] The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Soochow University Suzhou Medical College, Suzhou, Jiangsu, China. shaoc@suda.edu.cn. ^[4] The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Soochow University Suzhou Medical College, Suzhou, Jiangsu, China. yfshi@suda.edu.cn. ^[5]

关键词 Anti-tumor immunity Brain tumors CCR8 Glucocorticoid receptor T cell redistribution

主题词动物(Animals);受体, 糖皮质激素(Receptors, Glucocorticoid);脑肿瘤(Brain Neoplasms);受体, CCR8(Receptors, CCR8);小鼠(Mice);T淋巴细胞(T-Lymphocytes);小鼠, 近交C57BL(Mice, Inbred C57BL);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);骨髓细胞(Bone Marrow Cells)

DOI 10.1038/s41423-024-01202-5

PMID 39044027

发布时间 2024-10-03

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Cellular & molecular immunology

2024年21卷10期

1145-1157页

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Targeting the glucocorticoid receptor-CCR8 axis mediated bone marrow T cell sequestration enhances infiltration of anti-tumor T cells in intracranial cancers.

Cellular & molecular immunology

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Cellular & molecular immunology

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Targeting the glucocorticoid receptor-CCR8 axis mediated bone marrow T cell sequestration enhances infiltration of anti-tumor T cells in intracranial cancers.

Cellular & molecular immunology

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Cellular & molecular immunology

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