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Improving the Assessment of Risk Factors Relevant to Potential Carcinogenicity of Gene Therapies: A Consensus Article.

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第一作者: Jan C,Klapwijk
第一单位: Cornelis Consulting Ltd, London, United Kingdom.
作者单位: Cornelis Consulting Ltd, London, United Kingdom. [1] GentiBio Inc., Cambridge, Massachusetts, USA. [2] Novartis Biomedical Research, Basel, Switzerland. [3] Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom. [4] TestaVec Ltd, Maidenhead, United Kingdom.;Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, United Kingdom. [5] GlaxoSmithKline, Genetic Toxicology, Ware, United Kingdom. [6] National Centre for the Replacement Refinement and Reduction of Animals in Research, London, United Kingdom. [7] F. Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland. [8] UCL Zayed Centre for Research (ZCR), London, United Kingdom. [9] Cell and Gene Therapy, GSK Medicine Research Centre, Stevenage, United Kingdom. [10] Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, Pennsylvania, USA. [11] Institute for Transfusion Medicine and Gene Therapy, Medical Center- University of Freiburg, Freiburg, Germany.;Faculty of Medicine, University of Freiburg, Freiburg, Germany. [12] Ertl Laboratory, Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, USA. [13] ProtaGene CGT, Heidelberg, Germany. [14] Horae Gene Therapy Center, UMass Chan Medical School, University of Massachusetts, Worcester, Massachusetts, USA. [15] Center for Cellular Immunotherapies and Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. [16] Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom. [17] Drug Safety Research & Development, Pfizer, Inc., Groton, Connecticut, USA. [18] Department of Haematology, Blood Transplant and Cell Therapies Program, Westmead Hospital, Sydney, Australia.;NSW Health Pathology Blood Transplant and Cell Therapies Laboratory - ICPMR Westmead, Sydney, Australia.;Westmead Institute for Medical Research, Sydney, Australia.;Sydney Medical School, The University of Sydney, Sydney, Australia. [19] Gene & Cell Therapy Promotion Center, National Center for Child Health and Development, Tokyo, Japan. [20] Merck & Co., Inc., Boston, Massachusetts, USA. [21] Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom. [22] Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany. [23] Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [24] Department of Medicine, Divisions of Hematology and Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA.;TwinStrand Biosciences Inc., Seattle, Washington, USA. [25] Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.;Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [26] Kymera Therapeutics, Watertown, Massachusetts, USA. [27]
DOI 10.1089/hum.2024.033
PMID 39049734
发布时间 2026-03-26
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