Ropivacaine prompts ferroptosis to enhance the cisplatin-sensitivity of human colorectal cancer through SIRT1/Nrf2 signaling pathway.

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作者： Lian,Zeng ^[1] ; WenBo,Zhao ^[2] ; Tiantian,Han ^[2] ; Fangfang,Qing ^[3] ; Zhongshi,He ^[2] ; Qiang,Zhao ^[2] ; Ailin,Luo ^[1] ; Pengchao,Hu ^[4] ; Xudong,Ding ^[5] ; Zhen,Zhang ^[6]

作者单位： Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. ^[1] Department of Anesthesiology, Central Laboratory, Hubei Clinical Research Center of Parkinson's disease, Xiangyang Key Laboratory of Movement Disorders, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, 44100, China. ^[2] Department of Anesthesiology, Xiangyang No.1 People's Hospita, Jinzhou Medical University Union Training Base, Xiangyang, 44100, China. ^[3] Department of Anesthesiology, Central Laboratory, Hubei Clinical Research Center of Parkinson's disease, Xiangyang Key Laboratory of Movement Disorders, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, 44100, China. Electronic address: hupengchao0904@126.com. ^[4] Department of Rehabilitation Medicine, Clinical Medical Center for Rehabilitation Treatment of Dystonia Disease, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, 44100, China. Electronic address: dingxd1018@163.com. ^[5] Department of Anesthesiology, Central Laboratory, Hubei Clinical Research Center of Parkinson's disease, Xiangyang Key Laboratory of Movement Disorders, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, 44100, China. Electronic address: xss318@163.com. ^[6]

关键词 Apoptosis Cisplatin resistance Ferroptosis Human colorectal cancer cells (LOVO LOVO/DDP)Ropivacaine