The yin and yang of pioneer transcription factors: Dual roles in repression and activation.

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作者： Takeshi,Katsuda ^[1] ; Jonathan H,Sussman ^[2] ; Kenneth S,Zaret ^[3] ; Ben Z,Stanger ^[4]

作者单位： Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan. ^[1] Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[2] Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;The Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[3] Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.;Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[4]

关键词 Pioneer factors chromatin gene activation gene repression transcription factors

主题词动物(Animals);人类(Humans);细胞分化(Cell Differentiation);细胞谱系(Cell Lineage);染色质(Chromatin);核小体(Nucleosomes);转录因子(Transcription Factors)

DOI 10.1002/bies.202400138

PMID 39058903

发布时间 2025-01-09

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