Elimination of the extra chromosome of Dup15q syndrome iPSCs for cellular and molecular investigation.

导出 LinkOut

翻译打印收藏纠错

第一作者： Haruka,Munezane

第一单位： Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan; Takeda-CiRA (T-CiRA) Joint Program, 2-26-1, Muraoka-Higashi, Fujisawa 251-8555, Japan.

作者： Haruka,Munezane ^[1] ; Keiko,Imamura ^[2] ; Naoko,Fujimoto ^[1] ; Akitsu,Hotta ^[1] ; Hiroshi,Yukitake ^[3] ; Haruhisa,Inoue ^[4]

作者单位： Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan; Takeda-CiRA (T-CiRA) Joint Program, 2-26-1, Muraoka-Higashi, Fujisawa 251-8555, Japan. ^[1] Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan; Takeda-CiRA (T-CiRA) Joint Program, 2-26-1, Muraoka-Higashi, Fujisawa 251-8555, Japan; iPSC-based Drug discovery and Development Team, RIKEN BioResource Research Center, 1-7 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan; Medical-Risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. ^[2] Takeda-CiRA (T-CiRA) Joint Program, 2-26-1, Muraoka-Higashi, Fujisawa 251-8555, Japan; Global Advanced Platform, Takeda Pharmaceutical Company Limited, 2-26-1, Muraoka-Higashi, Fujisawa 251-8555, Japan. ^[3] Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan; Takeda-CiRA (T-CiRA) Joint Program, 2-26-1, Muraoka-Higashi, Fujisawa 251-8555, Japan; iPSC-based Drug discovery and Development Team, RIKEN BioResource Research Center, 1-7 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan; Medical-Risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: haruhisa@cira.kyoto-u.ac.jp. ^[4]

关键词 Autism spectrum disorders (ASDs)Cerebral organoids Chromosome 15q11.2-13.1 duplication (Dup15q) syndrome Copy number variants (CNVs)Isogenic cell line

主题词人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);染色体, 人, 15对(Chromosomes, Human, Pair 15);染色体重复(Chromosome Duplication);DNA拷贝数变异(DNA Copy Number Variations);类器官(Organoids);染色体畸变(Chromosome Aberrations)

DOI 10.1016/j.ejcb.2024.151446

PMID 39059105

发布时间 2024-08-15

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交