Single-cell analysis of human PBMCs in healthy and type 2 diabetes populations: dysregulated immune networks in type 2 diabetes unveiled through single-cell profiling.

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作者： Doeon,Gu ^[1] ; Jinyeong,Lim ^[1] ; Kyung Yeon,Han ^[2] ; In-Ho,Seo ^[3] ; Jae Hwan,Jee ^[4] ; Soo Jin,Cho ^[4] ; Yoon Ho,Choi ^[4] ; Sung Chul,Choi ^[4] ; Jang Hyun,Koh ^[4] ; Jin-Young,Lee ^[4] ; Mira,Kang ^[5] ; Dong-Hyuk,Jung ^[6] ; Woong-Yang,Park ^[7]

作者单位： Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea.;Samsung Genome Institute, Samsung Medical Center, Seoul, Republic of Korea. ^[1] Samsung Genome Institute, Samsung Medical Center, Seoul, Republic of Korea. ^[2] Department of Biomedical Science, College of Life Science CHA University, Gyeonggi-do, Republic of Korea. ^[3] Department of Health Promotion Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. ^[4] Department of Health Promotion Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.;Department of Digital Health, Samsung Advanced Institute of Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea.;Digital Transformation Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. ^[5] Department of Family Medicine, Yongin Severance Hospital, Gyeonggi-do, Republic of Korea. ^[6] Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea.;Samsung Genome Institute, Samsung Medical Center, Seoul, Republic of Korea.;Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. ^[7]

关键词 T cell cell interaction monocyte pro-inflammatory characteristics single-cell RNA sequencing type 2 diabetes