首页> Lung cancer (Amsterdam, Netherlands)> Treatment patterns and outcomes in KRAS<sup>G12C</sup>-positive advanced NSCLC patients previously treated with immune checkpoint inhibitors: A Canada-wide real-world, multi-center, retrospective cohort study.

Treatment patterns and outcomes in KRAS<sup>G12C</sup>-positive advanced NSCLC patients previously treated with immune checkpoint inhibitors: A Canada-wide real-world, multi-center, retrospective cohort study.

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第一作者： Samir H,Barghout

第一单位： Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.

作者： Samir H,Barghout ^[1] ; Luna Jia,Zhan ^[2] ; Starvroula,Raptis ^[2] ; Faisal,Al-Agha ^[2] ; Niki,Esfahanian ^[2] ; Aimee,Popovacki ^[3] ; Goulnar,Kasymjanova ^[4] ; Francis,Proulx-Rocray ^[5] ; Sze Wah Samuel,Chan ^[6] ; Matthew,Richardson ^[7] ; M Catherine,Brown ^[2] ; Devalben,Patel ^[2] ; Michelle Liane,Dean ^[8] ; Vishal,Navani ^[9] ; Erica,Moore ^[10] ; Lane,Carvery ^[3] ; Elizabeth,Yan ^[6] ; Daniel,Goldshtein ^[6] ; Jasmine,Cleary-Gosine ^[3] ; Amanda Jw,Gibson ^[8] ; Lynn,Hubley ^[3] ; Karmugi,Balaratnam ^[2] ; Tran,Ngo ^[3] ; Azee,Gill ^[11] ; Morgan,Black ^[12] ; Adrian,Sacher ^[2] ; Penelope A,Bradbury ^[2] ; Frances A,Shepherd ^[2] ; Natasha,Leighl ^[2] ; Parneet,Cheema ^[11] ; Sara,Kuruvilla ^[12] ; Jason,Agulnik ^[4] ; Shantanu,Banerji ^[10] ; Rosalyn,Juergens ^[6] ; Normand,Blais ^[5] ; Winson,Cheung ^[9] ; Paul,Wheatley-Price ^[7] ; Geoffrey,Liu ^[13] ; Stephanie,Snow ^[14]

作者单位： Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt. ^[1] Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. ^[2] Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada. ^[3] Jewish General Hospital, Montreal, QC, Canada. ^[4] Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada. ^[5] Juravinski Cancer Centre, Hamilton Health Sciences, Hamilton, ON, Canada. ^[6] University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON, Canada. ^[7] Glans-Look Lung Cancer Research, University of Calgary, Calgary, AB, Canada. ^[8] Glans-Look Lung Cancer Research, University of Calgary, Calgary, AB, Canada; Tom Baker Cancer Centre, Calgary, AB, Canada. ^[9] CancerCare Manitoba Research Institute, Winnipeg, MB, Canada. ^[10] Brampton Civic Hospital, William Osler Health System, Brampton, ON, Canada. ^[11] London Health Sciences Centre, London, ON, Canada. ^[12] Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Electronic address: Geoffrey.Liu@uhn.ca. ^[13] Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada. Electronic address: stephanie.snow@nshealth.ca. ^[14]

关键词 Advanced NSCLC Immune checkpoint inhibitors Immunotherapy KRAS(G12C)Non-small cell lung cancer Real-world data Sotorasib Systemic therapy Targeted therapy Treatment patterns